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four-AcO-copyright was first synthesized in 1963 by Albert Hofmann and Franz Troxler as Section of a chemical investigation into psilocin analogs.However, it wasn't analyzed for psychoactivity during this time. It can be not known when it was initially explored in people. A paper authored by David E. Nichols in 1999 proposed its likely use instead to psilocybin for pharmacological investigate because of the reduce cost of synthesis.

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